Entries by tag: vit d
EPIGENETICS OF DM2: GLUCOCORTICOID AND VIT D RECEPTORS MEDIATE
ALSO TNF ALPHA OR DEXAMETHASONE INDUCES IR
http://www.nature.com/ncb/journal/v17/n1/full/ncb3080.html
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis
Sona Kang, Linus T. Tsai, Yiming Zhou, Adam Evertts, Su Xu, Michael J. Griffin, Robbyn Issner, Holly J. Whitton, Benjamin A. Garcia, Charles B. Epstein, Tarjei S. Mikkelsen & Evan D. Rosen
Nature Cell Biology 17, 44–56 (2015) doi:10.1038/ncb3080
Received 06 August 2014 Accepted Nov 2014 Published online 15 Dec 2014
Abstract
Insulin resistance is a cardinal feature of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, ageing and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is known about the transcriptional and epigenetic basis of this disorder, despite evidence that such pathways are likely to play a fundamental role. Here, we compare cell autonomous models of insulin resistance induced by the cytokine tumour necrosis factor-α or by the steroid dexamethasone to construct detailed transcriptional and epigenomic maps associated with cellular insulin resistance. These data predict that the glucocorticoid receptor and vitamin D receptor are common mediators of insulin resistance, which we validate using gain- and loss-of-function studies. These studies define a common transcriptional and epigenomic signature in cellular insulin resistance enabling the identification of pathogenic mechanisms.
ALSO TNF ALPHA OR DEXAMETHASONE INDUCES IR
http://www.nature.com/ncb/journal/v17/n1/full/ncb3080.html
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis
Sona Kang, Linus T. Tsai, Yiming Zhou, Adam Evertts, Su Xu, Michael J. Griffin, Robbyn Issner, Holly J. Whitton, Benjamin A. Garcia, Charles B. Epstein, Tarjei S. Mikkelsen & Evan D. Rosen
Nature Cell Biology 17, 44–56 (2015) doi:10.1038/ncb3080
Received 06 August 2014 Accepted Nov 2014 Published online 15 Dec 2014
Abstract
Insulin resistance is a cardinal feature of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, ageing and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is known about the transcriptional and epigenetic basis of this disorder, despite evidence that such pathways are likely to play a fundamental role. Here, we compare cell autonomous models of insulin resistance induced by the cytokine tumour necrosis factor-α or by the steroid dexamethasone to construct detailed transcriptional and epigenomic maps associated with cellular insulin resistance. These data predict that the glucocorticoid receptor and vitamin D receptor are common mediators of insulin resistance, which we validate using gain- and loss-of-function studies. These studies define a common transcriptional and epigenomic signature in cellular insulin resistance enabling the identification of pathogenic mechanisms.
Supplements 101:
the Who What and Why of Dietary Supplement Manufacturing and Use in Clinical Practice
IATROGENIC AND OTC HYPOCHLORHYDRIA
tabs also not good for pts who are taking acid blocking meds (tagamet, etc)
without acid: don't digest proteins, don't absorb minerals
shakes bottle of tabs: as good as a maraca if you don't have acid
blocked acids in rats: made them more allergic to foods
http://www.ncbi.nlm.nih.gov/pubmed/17227952?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3
he asked the researcher, they're doing it in humans, same results
( guest lecturer week 7, this post has been moved forward in time: what forms of vitamins to take? good info here, esp on folate as relates to neurotransmitter manufactureCollapse )
the Who What and Why of Dietary Supplement Manufacturing and Use in Clinical Practice
IATROGENIC AND OTC HYPOCHLORHYDRIA
tabs also not good for pts who are taking acid blocking meds (tagamet, etc)
without acid: don't digest proteins, don't absorb minerals
shakes bottle of tabs: as good as a maraca if you don't have acid
blocked acids in rats: made them more allergic to foods
http://www.ncbi.nlm.nih.gov/pubmed/17227952?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3
he asked the researcher, they're doing it in humans, same results
( guest lecturer week 7, this post has been moved forward in time: what forms of vitamins to take? good info here, esp on folate as relates to neurotransmitter manufactureCollapse )
I haven't used sunscreen since I moved to Oregon. Here, the sun feels weak to me. I also haven't had a sunburn since I moved here, though a few times my shoulders or nose has got pink. In Arizona I used to wear sunscreen but gradually transitioned over to using long sleeves, long pants, and a big hat. I would put sunscreen on my lower face, nose, ears, neck, and the backs of my hands and tops of my feet. Here I still favor a hat and sleeves: the lotions always felt gross to me. The ones that didn't feel gross washed off too easy (kayaking) and didn't do any good. So that's my take on sunscreen. Not highly educated---I didn't even really dig into the site linked below I have a few types around the house and I'm afraid to look them up and see how carcinogenic they are. I know some of the chemicals used aren't great. I've heard that the zinc-containing kinds are most effective and least dangerous.
Sunscreen picker:
http://breakingnews.ewg.org/2011sunscreen/?inlist=Y&utm_source=2011sunscreenfull&utm_medium=email&utm_content=image&utm_campaign=toxics
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