Entries by tag: obesity
We used to live in a world where people got sick from exposure to feces and lives were saved with antibiotics. Now we live in a world where people are dying from antibiotics and their lives are being saved by feces.
--a colleague
--a colleague
EPIGENETICS OF DM2: GLUCOCORTICOID AND VIT D RECEPTORS MEDIATE
ALSO TNF ALPHA OR DEXAMETHASONE INDUCES IR
http://www.nature.com/ncb/journal/v17/n1/full/ncb3080.html
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis
Sona Kang, Linus T. Tsai, Yiming Zhou, Adam Evertts, Su Xu, Michael J. Griffin, Robbyn Issner, Holly J. Whitton, Benjamin A. Garcia, Charles B. Epstein, Tarjei S. Mikkelsen & Evan D. Rosen
Nature Cell Biology 17, 44–56 (2015) doi:10.1038/ncb3080
Received 06 August 2014 Accepted Nov 2014 Published online 15 Dec 2014
Abstract
Insulin resistance is a cardinal feature of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, ageing and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is known about the transcriptional and epigenetic basis of this disorder, despite evidence that such pathways are likely to play a fundamental role. Here, we compare cell autonomous models of insulin resistance induced by the cytokine tumour necrosis factor-α or by the steroid dexamethasone to construct detailed transcriptional and epigenomic maps associated with cellular insulin resistance. These data predict that the glucocorticoid receptor and vitamin D receptor are common mediators of insulin resistance, which we validate using gain- and loss-of-function studies. These studies define a common transcriptional and epigenomic signature in cellular insulin resistance enabling the identification of pathogenic mechanisms.
ALSO TNF ALPHA OR DEXAMETHASONE INDUCES IR
http://www.nature.com/ncb/journal/v17/n1/full/ncb3080.html
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis
Sona Kang, Linus T. Tsai, Yiming Zhou, Adam Evertts, Su Xu, Michael J. Griffin, Robbyn Issner, Holly J. Whitton, Benjamin A. Garcia, Charles B. Epstein, Tarjei S. Mikkelsen & Evan D. Rosen
Nature Cell Biology 17, 44–56 (2015) doi:10.1038/ncb3080
Received 06 August 2014 Accepted Nov 2014 Published online 15 Dec 2014
Abstract
Insulin resistance is a cardinal feature of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, ageing and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is known about the transcriptional and epigenetic basis of this disorder, despite evidence that such pathways are likely to play a fundamental role. Here, we compare cell autonomous models of insulin resistance induced by the cytokine tumour necrosis factor-α or by the steroid dexamethasone to construct detailed transcriptional and epigenomic maps associated with cellular insulin resistance. These data predict that the glucocorticoid receptor and vitamin D receptor are common mediators of insulin resistance, which we validate using gain- and loss-of-function studies. These studies define a common transcriptional and epigenomic signature in cellular insulin resistance enabling the identification of pathogenic mechanisms.
Statistics show that the "stroke belt" is also where you have the highest likelihood (in the US) of dying of cardiovascular and lower respiratory disease (smoking), cancer and accidents. Obesity, diabetes and metabolic syndrome are probable causes, but what about accidents? Why do southerners have the most accidents? Bless their dangerous little hearts....
SOURCE
http://consumer.healthday.com/cardiovascular-health-information-20/heart-attack-news-357/southeastern-states-have-highest-number-of-preventable-deaths-687436.html
SOURCE
http://consumer.healthday.com/cardiovascular-health-information-20/heart-attack-news-357/southeastern-states-have-highest-number-of-preventable-deaths-687436.html
http://www.medpagetoday.com/PrimaryCare/Obesity/44170?xid=nl_mpt_DHE_2014-02-07
((This brings up the question: could global warming be a factor in the obesity epidemic??))
((This brings up the question: could global warming be a factor in the obesity epidemic??))
If Americans snacked only occasionally, and in small amounts, this would not present the enormous problem that it does. But because so much money and effort has been invested over decades in engineering and then relentlessly selling these products, the effects are seemingly impossible to unwind. More than 30 years have passed since Robert Lin first tangled with Frito-Lay on the imperative of the company to deal with the formulation of its snacks, but as we sat at his dining-room table, sifting through his records, the feelings of regret still played on his face. In his view, three decades had been lost, time that he and a lot of other smart scientists could have spent searching for ways to ease the addiction to salt, sugar and fat. “I couldn’t do much about it,” he told me. “I feel so sorry for the public.”
SOURCE
NY Times article on the science behind Addictive Food. For sure, the objective is profits, not health.
http://www.nytimes.com/2013/02/24/magazine/the-extraordinary-science-of-junk-food.html?pagewanted=all&_r=1&
SOURCE
NY Times article on the science behind Addictive Food. For sure, the objective is profits, not health.
http://www.nytimes.com/2013/02/24/magazine/the-extraordinary-science-of-junk-food.html?pagewanted=all&_r=1&
This is some pretty wild new info. According to Mercola, cooling the palms of the hands may activate brown fat cells causing more fat to burn. Burn baby burn.
http://fitness.mercola.com/sites/fitness/archive/2012/03/30/hand-cooling-device-for-effective-workout.aspx?e_cid=20120330_FNL_art_1
http://fitness.mercola.com/sites/fitness/archive/2012/03/30/hand-cooling-device-for-effective-workout.aspx?e_cid=20120330_FNL_art_1
http://www.cdc.gov/obesity/data/trends.html
You can check out the progress of America's increasing BMI by state, since 1985, on this govt page. The South leads the charge.
Colorado is the Rocky Mountain holdout but they are sliding too.
You can check out the progress of America's increasing BMI by state, since 1985, on this govt page. The South leads the charge.
Colorado is the Rocky Mountain holdout but they are sliding too.
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