Noon talk in room 301 at NUNM "Biofilms == What has the last 200-Million Dollars in Research Taught Us" copyrighted powerpoint--PS anderson www.consultDrA.com
his presentation: evaluation of biofilm research clinical relevance
10 yrs ago involved in cancer research at Bastyr, 5 yr NIH trial next research--undiagnosable nonhealing illnesses junk drawer dxs: fibromyalgia, rheumatologic conditions not well differentiated what were impediments to cure? nutrigenomics multiple causes, multiple organ systems involved, often dxd as rheumatologic condition most had lab verifiable infections, not cleared by usual treatments
research review 20 years later NIH and CDC have ID'd biofilms as highest threat to human health but haven't publicized it because they don't know what to do about it
clinically trying things, some worked, some didn't doing OK a few years forward--at oncology think tank meeting met a guy doing biofilm research, 12 million dollars funding, 11 million in Anderson's Q's last million will be FDA approved interventions for biofilms government "disappears" some of the research he got more sources from this guy, looked at the research, is sharing sources with us in his powerpoint
biofilm becomes a resistance factor for the microbe resistant to antibiotics
lives "anyplace wet": blood vessels, mouth, (me: what about gut, lungs/bronchi, sinuses?) biofilms start in the gut and get more severe, cause significant immune response when disrupted sick long enough: more microbes migrate there it gets bigger, from thin to thick, from low diversity to high the worst biofilms are "phase 2" become their own microbe can contain bacteria, parasites, viruses, fungi--they share DNA treatments don't work: kill one but the rest survive cure one thing and another thing pops up
clinically relevant in sicker population, chronically ill lots of suppressive treatments, incomplete treatment many microbes involved pseudomonas and gram negatives mycoplasma H. pylori (symptomatic)
treatments for phase 1 are enzymes and such work pretty well patients usually not that sick
Biofilm summary from Stephen E. Fry MD (in power point) Biofilms are considered the rule in nature rather than the exceptoin. If you have chronic infection, biofilms may be an underlying cause. Many, if not most, ....
testing for biofilms can't really?
prevention - phase 1 agents goals: inhibit quorum sensing, initial attachment, organism efflux pump MORE ON THIS SLIDE enzymes aromatics--oregano, garlic, olive, etc (daily consumption of these = best prevention) tannins phenolics xylitol, stevia nigella = black cumin--can be used for phase 2 as well, plant immune modulators, wedges into biofilms
phase 2 later biofilm not treatable with phase 1 agents except black cumin synthetic antimicrobials direct biofilm disruption--agents - ?? PO, IV product: biocidin, he likes it, goes to phase 1.5 ish
oral bismuth (ionic) EDTA, calcium-disodium EDTA and Na2-EDTA as additive to immune and abx IV formulas for pts who may have biofilm silver nanoparticles, low 23 PPM nasal spray or 200-500ppm for other systems, hydrosol not colloidal anti-infective: H2o2, HDIVC, Ge, Zn, etc
BEG bactroban, e and gentamycin
thiols (mono-) ALA (Oral or IV), NAC (oral or IV, or nebulized for resp), glutathione (IV or nebulized) (ala and nac will cause strange gut reactions when added, this indicates that there's a biofilm) thiols (di-) DMSA (oral, 300-500mg po away from food bid day prior to and of the IV anti-infective), DMPS (IV and oral)
oral bismuth-thiol complex--neither alone, a new molecule (do not use IV bismuth at this time, heavy metal) combo: the last million he hadn't figured out yet little to no chelation effect. dithiol is bound to bismuth so toxicity of bismuth and chelating ability are "negated" bismuth nontoxic in this form, new mol will show up on heavy metal testing as bismuth wedges into the biofilm and reacquaints the immune system with what's in there: the "wedge effect"
HIS FORMULA: DMPS 25mg, ALA 100mg, bismuth subnitrate 200mg per cap ideally no substitutions DMSA 100mg can sub for DMPS bismuth subcitrate can sub for subnitrate (weaker product) this is the strongest formula that can be made, stronger products have been sequestered by the govt
take for 60 days---more on slide
other supports needed for about a month many need adrenal support if on low dose hydrocrotisone and adrenal support they will probably need 2-4x more hydrocorisone if on non-rx adrenal support they may need 5-10x the dose for "a time" some need thyroid support
his otc version Bis-thiol plus buck cumin
support immune system during tx support healthy microbiome
when biofilm opens up you get an immune response achy, headache, fever, possible psych sx can be big crisis if you are not ready for it very acute must warn patient ahead of time--if they start feeling terrible that's a good sign return of early sx is likely: sign of treatment success if healing crisis does not subside: bugs dying releasing metallotoxins or broad spectrum herbals aren't heavy duty enough duration of treatment relates to duration of illness, up to 2 years
immune suppressed patient won't get fever, cytokine storm treat presumptively, prescription anti-infectives to hedge bets
Pain = --a feeling of distress, suffering, or agony, --an unpleasant sensation that can range from mild, localized discomfort to agony --has physical and emotional components --emotions have strong effects on physical perception --algophobia = an irrational dread of pain --depression etc strongly associated with inadequately treated pain --also "pain" = painful uterine contraction occurring in childbirth. --from the Latin "poena" meaning a fine, a penalty --acute or nociceptive pain vs neuropathic pain --nociceptive and neuropathic pain are caused by different neuro–physiological processes, and therefore tend to respond to different treatment modalities ( moreCollapse )
I felt some loneliness the first week I was here. But now, no. I have enough acquaintances to not feel lonely. The landlady, Marie, speaks English and her bf is American. And her niece, Emma, also…
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