Entries by tag: disease
Living in an urban area I, like many, exercise in the park. I was doing so before the pandemic started and I have continued. My local park is big and beautiful and is seeing a higher level of use now that the gyms are closed. It feels safe and reasonable except for one thing: the runners who brush past on the paved trails. They are too close; many runners are making no effort to distance from others who use the same trails. This is not good enough.
Runners, please run farther away from the other people who use public trails. In most cases you can run off trail to give people, especially elders, a wide berth. Consider it part of your workout. Elders are much less able to avoid you than you are to avoid them. Running up behind people does not give them an opportunity to avoid you. There are sections of trail that are restricted in width--you can choose different routes. Some runners have taken to running on sidewalks and side streets to avoid too-close pedestrians. This is reasonable and appreciated, and might make it possible for you to enter that thoughtless consciousness that some runners enjoy.
If you are young or Republican and "not worried" about the virus, that does not make it acceptable for you to frighten or expose others. A certain amount of kindness is expected just because you are part of the human family. Thoughtlessness and selfishness are not admirable, and I don't think anyone wants to be that way. We all have the potential to be better than that, to be conscientious and caring in our interactions with each other. So please, runners, take the extra steps to let all people have a minimum of six feet distance, no matter who they are. I for one thank you for this kindness.
"Biofilms == What has the last 200-Million Dollars in Research Taught Us"
copyrighted powerpoint--PS anderson
www.consultDrA.com
his presentation:
evaluation of biofilm research
clinical relevance
10 yrs ago involved in cancer research at Bastyr, 5 yr NIH trial
next research--undiagnosable nonhealing illnesses
junk drawer dxs: fibromyalgia, rheumatologic conditions not well differentiated
what were impediments to cure?
nutrigenomics
multiple causes, multiple organ systems involved, often dxd as rheumatologic condition
most had lab verifiable infections, not cleared by usual treatments
research review 20 years later
NIH and CDC have ID'd biofilms as highest threat to human health
but haven't publicized it because they don't know what to do about it
clinically trying things, some worked, some didn't
doing OK
a few years forward--at oncology think tank meeting
met a guy doing biofilm research, 12 million dollars funding, 11 million in Anderson's Q's
last million will be FDA approved interventions for biofilms
government "disappears" some of the research
he got more sources from this guy, looked at the research, is sharing sources with us in his powerpoint
biofilm becomes a resistance factor for the microbe
resistant to antibiotics
lives "anyplace wet": blood vessels, mouth, (me: what about gut, lungs/bronchi, sinuses?)
biofilms start in the gut and get more severe, cause significant immune response when disrupted
sick long enough: more microbes migrate there
it gets bigger, from thin to thick, from low diversity to high
the worst biofilms are "phase 2" become their own microbe
can contain bacteria, parasites, viruses, fungi--they share DNA
treatments don't work: kill one but the rest survive
cure one thing and another thing pops up
clinically relevant in sicker population, chronically ill
lots of suppressive treatments, incomplete treatment
many microbes involved
pseudomonas and gram negatives
mycoplasma
H. pylori (symptomatic)
treatments for phase 1 are enzymes and such
work pretty well
patients usually not that sick
Biofilm summary from Stephen E. Fry MD (in power point)
Biofilms are considered the rule in nature rather than the exceptoin. If you have chronic infection, biofilms may be an underlying cause. Many, if not most, ....
testing for biofilms
can't really?
prevention - phase 1 agents
goals: inhibit quorum sensing, initial attachment, organism efflux pump
enzymes
aromatics--oregano, garlic, olive, etc (daily consumption of these = best prevention)
tannins
phenolics
xylitol, stevia
nigella = black cumin--can be used for phase 2 as well, plant immune modulators, wedges into biofilms
phase 2 later biofilm
not treatable with phase 1 agents except black cumin
synthetic antimicrobials
direct biofilm disruption--agents - ?? PO, IV
product: biocidin, he likes it, goes to phase 1.5 ish
oral bismuth (ionic)
EDTA, calcium-disodium EDTA and Na2-EDTA as additive to immune and abx IV formulas for pts who may have biofilm
silver nanoparticles, low 23 PPM nasal spray or 200-500ppm for other systems, hydrosol not colloidal
anti-infective: H2o2, HDIVC, Ge, Zn, etc
BEG bactroban, e and gentamycin
thiols (mono-) ALA (Oral or IV), NAC (oral or IV, or nebulized for resp), glutathione (IV or nebulized)
(ala and nac will cause strange gut reactions when added, this indicates that there's a biofilm)
thiols (di-) DMSA (oral, 300-500mg po away from food bid day prior to and of the IV anti-infective), DMPS (IV and oral)
oral bismuth-thiol complex--neither alone, a new molecule (do not use IV bismuth at this time, heavy metal)
combo: the last million he hadn't figured out yet
little to no chelation effect. dithiol is bound to bismuth so toxicity of bismuth and chelating ability are "negated"
bismuth nontoxic in this form, new mol will show up on heavy metal testing as bismuth
wedges into the biofilm and reacquaints the immune system with what's in there: the "wedge effect"
HIS FORMULA:
DMPS 25mg, ALA 100mg, bismuth subnitrate 200mg per cap
ideally no substitutions
DMSA 100mg can sub for DMPS
bismuth subcitrate can sub for subnitrate (weaker product)
this is the strongest formula that can be made, stronger products have been sequestered by the govt
take for 60 days---more on slide
other supports needed for about a month
many need adrenal support
if on low dose hydrocrotisone and adrenal support they will probably need 2-4x more hydrocorisone
if on non-rx adrenal support they may need 5-10x the dose for "a time"
some need thyroid support
his otc version
Bis-thiol plus buck cumin
support immune system during tx
support healthy microbiome
when biofilm opens up you get an immune response
achy, headache, fever, possible psych sx
can be big crisis if you are not ready for it
very acute
must warn patient ahead of time--if they start feeling terrible that's a good sign
return of early sx is likely: sign of treatment success
if healing crisis does not subside: bugs dying releasing metallotoxins or broad spectrum herbals aren't heavy duty enough
duration of treatment relates to duration of illness, up to 2 years
immune suppressed patient
won't get fever, cytokine storm
treat presumptively, prescription anti-infectives to hedge bets
this article has all the same references as this talk
http://ndnr.com/gastrointestinal/biofilms-what-have-we-learned-from-the-research/
and webinar on priority one
fasting?
get stronger/faster reaction with it
We need to listen to the patients' story
and develop a response to it.
The approach to complex syndromes
may be much more profound
than just trying to point a round peg into a square hole
and get a singular diagnosis.
--Jeffrey S. Bland, PhD
The relief of suffering and the cure of disease
must be seen as twin obligations
of a medical profession that is truly dedicated to the care of the sick.
Physicians' failure to understand the nature of suffering
can result in medical intervention
that (though technically adequate) not only fails to relieve suffering
but becomes a source of suffering itself.
--Eric J. Cassell
--a colleague
http://www.evolutionnews.org/2006/04/doctor_doom_eric_pianka_receiv002118.html
We are not the only or most important species, but we think we are.
Somehow it helps me to keep the big picture in mind. We live, then we die. Our species rises to dominance, then fades. The planet goes on. The Universe goes on.
- Current Mood:
contemplative
MERS is the viral infection that's causing severe respiratory disease in lots of folks over there. There have been just a few cases in the US, starting in May. I'm wondering if military personel are coming back sick? Apparently pretty much all of the camels on the Arabian peninsula have this virus. We don't know if it causes chronic infections, but I wouldn't be surprised if it did, considering what we are learning about viral DNA mingled with our own.
what’s the point of curing one disease
—we’ll just get another.
--Nir Barzilai
Types of Plastic:
1 PET
2 HDFE
3 PVC (rafts)
4 CDPE (bags)
5 PP
6 PS (polystyrene)
7 Other
I posted once about the Great Pacific Waste Dump, basically just parroting media hype. It turns out the plastic in the ocean is mostly in tiny bits instead of in a big island of capped bottles. It is thickest in the five GYRES on the planet, which appear to me to be doldrums where there are no tradewinds or strong currents. The most directly alarming thing about the litter of plastic bits is that it is covered in life that is migrating in a whole new way. Barnacles, biofilm and plankton all hitch a ride or get tangled in the mess. We had NO IDEA what this is going to mean in the long run. A new name has been coined for all the microorganisms on the polypropylene and polyethlene in the ocean: the Plastisphere. The only organism named by Emelia DeForce PhD in last night's Science Pub talk was Vibrio, the same genus as cholera. I was dying to ask if MRSA was on the plastic around Hawaii but we left because the line was long and we were done. All the factoids in this post are courtesy of Dr DeForce.
Plastic is made from crude oil into nerdles (sp?), which are small balls of hard petroleum product. Those can then be shipped to the manufacturers who combine them with additives and make their product.
cancer cells are hyperactive, survival-endowed,
scrappy, fecund, inventive copies of ourselves.
--Siddhardtha Mukherjee in The Emperor of All Maladies
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