Noon talk in room 301 at NUNM
"Biofilms == What has the last 200-Million Dollars in Research Taught Us"
copyrighted powerpoint--PS anderson
www.consultDrA.com

his presentation:
evaluation of biofilm research
clinical relevance

10 yrs ago involved in cancer research at Bastyr, 5 yr NIH trial
next research--undiagnosable nonhealing illnesses
junk drawer dxs: fibromyalgia, rheumatologic conditions not well differentiated
what were impediments to cure?
nutrigenomics
multiple causes, multiple organ systems involved, often dxd as rheumatologic condition
most had lab verifiable infections, not cleared by usual treatments

research review 20 years later
NIH and CDC have ID'd biofilms as highest threat to human health
but haven't publicized it because they don't know what to do about it

clinically trying things, some worked, some didn't
doing OK
a few years forward--at oncology think tank meeting
met a guy doing biofilm research, 12 million dollars funding, 11 million in Anderson's Q's
last million will be FDA approved interventions for biofilms
government "disappears" some of the research
he got more sources from this guy, looked at the research, is sharing sources with us in his powerpoint

biofilm becomes a resistance factor for the microbe
resistant to antibiotics

lives "anyplace wet": blood vessels, mouth, (me: what about gut, lungs/bronchi, sinuses?)
biofilms start in the gut and get more severe, cause significant immune response when disrupted
sick long enough: more microbes migrate there
it gets bigger, from thin to thick, from low diversity to high
the worst biofilms are "phase 2" become their own microbe
can contain bacteria, parasites, viruses, fungi--they share DNA
treatments don't work: kill one but the rest survive
cure one thing and another thing pops up

clinically relevant in sicker population, chronically ill
lots of suppressive treatments, incomplete treatment
many microbes involved
pseudomonas and gram negatives
mycoplasma
H. pylori (symptomatic)

treatments for phase 1 are enzymes and such
work pretty well
patients usually not that sick

Biofilm summary from Stephen E. Fry MD (in power point)
Biofilms are considered the rule in nature rather than the exceptoin.  If you have chronic infection, biofilms may be an underlying cause.  Many, if not most, ....

testing for biofilms
can't really?

prevention - phase 1 agents
goals: inhibit quorum sensing, initial attachment, organism efflux pump
MORE ON THIS SLIDE
enzymes
aromatics--oregano, garlic, olive, etc (daily consumption of these = best prevention)
tannins
phenolics
xylitol, stevia
nigella = black cumin--can be used for phase 2 as well, plant immune modulators, wedges into biofilms

phase 2 later biofilm
not treatable with phase 1 agents except black cumin
synthetic antimicrobials
direct biofilm disruption--agents - ?? PO, IV
product: biocidin, he likes it, goes to phase 1.5 ish

oral bismuth (ionic)
EDTA, calcium-disodium EDTA and Na2-EDTA as additive to immune and abx IV formulas for pts who may have biofilm
silver nanoparticles, low 23 PPM nasal spray or 200-500ppm for other systems, hydrosol not colloidal
anti-infective: H2o2, HDIVC, Ge, Zn, etc

BEG bactroban, e and gentamycin

thiols (mono-) ALA (Oral or IV), NAC (oral or IV, or nebulized for resp), glutathione (IV or nebulized)
(ala and nac will cause strange gut reactions when added, this indicates that there's a biofilm)
thiols (di-) DMSA (oral, 300-500mg po away from food bid day prior to and of the IV anti-infective), DMPS (IV and oral)

oral bismuth-thiol complex--neither alone, a new molecule (do not use IV bismuth at this time, heavy metal)
combo: the last million he hadn't figured out yet
little to no chelation effect.  dithiol is bound to bismuth so toxicity of bismuth and chelating ability are "negated"
bismuth nontoxic in this form, new mol will show up on heavy metal testing as bismuth
wedges into the biofilm and reacquaints the immune system with what's in there: the "wedge effect"

HIS FORMULA:
DMPS 25mg, ALA 100mg, bismuth subnitrate 200mg per cap
ideally no substitutions
DMSA 100mg can sub for DMPS
bismuth subcitrate can sub for subnitrate (weaker product)
this is the strongest formula that can be made, stronger products have been sequestered by the govt

take for 60 days---more on slide

other supports needed for about a month
many need adrenal support
if on low dose hydrocrotisone and adrenal support they will probably need 2-4x more hydrocorisone
if on non-rx adrenal support they may need 5-10x the dose for "a time"
some need thyroid support

his otc version
Bis-thiol plus buck cumin

support immune system during tx
support healthy microbiome

when biofilm opens up you get an immune response
achy, headache, fever, possible psych sx
can be big crisis if you are not ready for it
very acute
must warn patient ahead of time--if they start feeling terrible that's a good sign
return of early sx is likely: sign of treatment success
if healing crisis does not subside: bugs dying releasing metallotoxins or broad spectrum herbals aren't heavy duty enough
duration of treatment relates to duration of illness, up to 2 years

immune suppressed patient
won't get fever, cytokine storm
treat presumptively, prescription anti-infectives to hedge bets

this article has all the same references as this talk
http://ndnr.com/gastrointestinal/biofilms-what-have-we-learned-from-the-research/
and webinar on priority one

fasting?
get stronger/faster reaction with it

The Russians have known about phages and used them to treat severe infections since the 1930's. New research shows that lots of phages live in mucus. Wherever there is mucus there is likely to be a large population of phages--including mucus produced by other species such as sea coral, plants, etc.

Phages are viruses that use bacterial cells to replicate in. They can also insert new DNA into bacteria, and they are able to evolve quickly enough to keep up with changing resistance patterns. Big Pharma is not putting any money toward phage research because phage therapy would compete with antibiotic sales, and as we know, for them, the bottom line IS the bottom line. They want us to think that phages are dangerous. But according to Dr Mercola a normal human produces approximately a quart of mucus (snot) daily in the upper respiratory tract, most of which we swallow. So we are phage central already.
( notes from Mercola's new article on phagesCollapse )

Or in other words, they are a natural part of our immune defense! New science suggests that mucus in our body is full of viruses that attack bacteria! Those viruses don't hurt us, in fact, they protect us. Commensal viruses....
( the article from LifeCollapse )

NOBEL PRIZE-WINNING VIROLOGIST'S NEW RESEARCH GIVES SIGNIFICANT SUPPORT TO HOMEOPATHIC PHARMACOLOGY
( This article was emailed out to everyone in my class at NCNM. The premise is that pathogenic bacteria and viruses have certain DNA sequences that induce distinctive electromagnetic waves at very high aqueous dilutions. This phenomenon is supposed to be due to resonance triggered by the ambient electromagnetic background of very low frequency waves. The EM signature is strongest at dilutions at a range corresponding with the homeopathic dilutions of 5x to 12x, and needs to be shaken violently to form. Furthermore it does not occur if the sample is frozen or heated....all of these findings are the same as what homeopaths say about their medicine. Last but not least, the researchers are said to have found the same EM signals in the plasma and DNA of patients with Alzheimer's, Parkinson's, MS and RA. Can't wait until they figure out how to cure all that. Check out the way this article is written, using big words and high associations to gain status for homeopathy.Collapse )

The question I'm to answer is this:
Some bacteria (e.g. Salmonella typhi, Yersinia pestis, Rickettsiae, Mycobacteria) are known to penetrate and grow in the intracellular spaces inside host cells. What advantage does this environment have for the bacterium?
( boring bacterial notesCollapse )

There's this lovely bacterium called Listeria monocytogenes that is gram positive and likes to grow in dairy products. It doesn't produce any toxins or spores, it just gets in your cells and kills them. It gets started invading your body via the gut (gastroenteritis), but can take over much more of your body (invasive disease) given enough time. It is one of just a few bacteria that gets inside of your own cells (though this is standard practice for viruses) using a "zipper" mechanism. Once Listeria is inside your cells, the normal macrophage cleanup crew can't find it. It swims inside of host cells by making actin polymers! Listeria can grow at 4 degrees celcius, and is one good reason to we keep meats frozen.

Some 500 deaths/year are caused by Lysteria, and the pregnant woman and baby are most suceptible. The most common way for a pregnant mother to be exposed is by eating soft cheese. The first signs/symptoms of gastroenteritis are watery diarrhea (no blood), fever and headache, myalgias (flu-like). No vomiting. If a 1-4 week old newborn has meningitis, suspect Listeria. It can also get in the placenta during pregnancy and cause sepsis and abortion. Tx for invasive disease: ampicillin.
( and more: on Clostridium (four species including the ones that cause botulism and lockjaw)Collapse )