liveonearth (liveonearth) wrote,

Mercury and Lead Toxicity

dental amalgam source
pts with ideopathic dilated cardiomyopathy had 200,000 more mercury than controls
Minamata-Hg compounds dumped into bay--people in town began to develop strange symptoms, numbness in lipms and lips, difficulting seeing or hearing, shaking (tremors) in arms and legs, difficulty walking, brain damage.
Children were born in town with severe deformities, gnarled limbs, mental retardation, deafness and blindness

lead absorption causes Zn, Ca, Fe def
children absorb 4-5x more lead
for adulst inhalation primary source, for kids ingestion
lead storage: 85% bones, 10-15% teeht
predominantly excreted by kidneys
lead binds sulfhydryl groups, denatures proteins, affects calcium metabolism, affects membrane pumps (Na/K), affects CNS/PNS, decreases active vitamin D production

clinical effects:
hypochromic microcytic anemia with basophillip stilling
incr zinc protoporphyrin and free erythrocyte protoporphyrin because Pb inhibits Fe being placed in heme molecule: no ferrochetalase
CNA in kids: decr IG, learning disabilities, delayed motor and emotional development
PNS in adults, can be misdiagnosed as MS
lead "colic" pulling sensation on umbilicus
lead line on gums
lead line at empiphysis in children

sources of lead
pica: food, dust, crayons
parental occupation
kids absorb more lead when exposed and more likely to get cns sx
BBB more permeable first 3 yrs of life
for adults: mining, batteries, ammo, pipes, cans, gasoline, shooting galleries, homemade whiskey, leaded crystals, hair dye, contaminated mineral supplements

SSL's pathology 1 notes, 2010
Tags: bones, guns, heavy metals, japan, lead, mercury, nervous system, parenting, pathology

  • Wolverine Watchmen: Wannabe X-men vs the Feds

    I've been interested in human xenophobia (which I think is instinctive) and race and class warfare since I become politically aware some time in…

  • QotD: Gatofeo

    An ugly cat. Vast desert. Smoke and fire. Flying lead makes holes in parchment. The ugly cat is much amused. --- Gatodamus (1503-1566)…

  • Book: Pure Land

    Just finished this book by Annette McGivney. I ran across it because of a review in the Boatman's Quarterly, and got it from the local library. It…

  • Post a new comment


    Comments allowed for friends only

    Anonymous comments are disabled in this journal

    default userpic

    Your reply will be screened

    Your IP address will be recorded