liveonearth (liveonearth) wrote,

Topical Anesthetics: Cocaine

I look up cocaine and find this impressive list of slang about it. My goodness. I have never tried it in any form. It was "discovered" in 1860 when someone happened to notice that tasting it numbs the tongue. Pretty soon everybody was using it for toothaches, and in 1894 doctors started using it as a local anesthetic for surgeries, especially to the nose, eyes (lacrimal ducts!), and sinuses. Freud didn't think it was addictive, but it is, because it activates the mesolimbic dopamine pathway, the reward and desire pathway, the addiction pathway. Cocaine is a dopamine reuptake inhibitor. It is also a serotonin and norepinephrine reuptake inhibitor. But these effects should not happen if it is a tiny local dose. The local numbing effect occurs because cocaine blocks nerve permeability to sodium, preventing nerve transmission. The vasoconstrictive effect is due to the inhibition of norepi reuptake. Cocaine is the only anesthetic that is vasoconstrictive, the rest vasodilate necessitating the use of injected epinephrine to minimize bleeding and loss of the anesthetic into the systemic circulation. Can anybody tell me where the world's bounty of cocaine is coming from these days?
Tags: addiction, dopamine, drugs, norepi, pain, pharmacology, serotonin, surgery, teeth

  • Boiron Attempts Hypnosis to Save Homeopathy Market

    On Monday October 14 I attended what was advertised as a movie about homeopathy. It was listed in the email that goes out to all staff, faculty…

  • Sex and Sexism

    It's 3:44 am and I've been restless, unsleeping. I slept at first then woke with thoughts of Epstein, who just suicided because he didn't want to…

  • Poem: Let there be spaces in your togetherness

    Let there be spaces in your togetherness, And let the winds of the heavens dance between you. Love one another but make not a bond of love: Let…

  • Post a new comment


    Comments allowed for friends only

    Anonymous comments are disabled in this journal

    default userpic

    Your reply will be screened

    Your IP address will be recorded