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Acromegaly

What are the face, skull and foot changes seen with acromegaly?


ACROMEGALY
--dt pituitary eosinophilic adenoma secreting growth hormone AFTER growth plates have fused

--excessive growth hormone production PRIOR to closure of long bone growth ctrs-->gigantism:


-->back to acromegaly

--facial changes: prominent forehead, thickened tongue

--hands: broad and large, widened shafts, bony protuberances, enlarged distal tufts (spade like), widened joint spaces (dt cartilage overgrowth)


--predisposition to degenerative arthritis, esp of spine and weight bearing jts
--predisposition to carpal tunnel syndrome dt extra bone @ tendon attachments
--feet: heel pds greater than 20mm thick dt soft tissue and spurs

--spine: increased size, hyperostoses, widened disc heights, posterior body scalloping
--skull: sella turcica enlargement (dt pituitary neoplasm), sinus overgrowth (esp frontal), malocclusion, widened mandibular angle (prognathism, jaw goes down not forward)
--prognathism:

--sella turcica and frontal sinus here:


Treatment flowchart:

Comments

( 7 comments — Leave a comment )
neptunia67
Mar. 17th, 2009 03:27 pm (UTC)
Wow, that's a trip. People get some strange afflictions, don't they.
liveonearth
Mar. 17th, 2009 03:34 pm (UTC)
It takes all kinds. From cruising the pictures on the internet, I'd say that people born with acromegaly have high odds of ending up "freaks" or giants at circuses....
machmed
Mar. 17th, 2009 04:48 pm (UTC)
Ok, I'm kind of squeamish, so I really hate how I have to look at that every time I scroll down my friend's page. :(
liveonearth
Mar. 18th, 2009 03:16 am (UTC)
Is it the skull or the feet that bother you?
machmed
Mar. 18th, 2009 05:38 am (UTC)
The icky feet. :x
liveonearth
Mar. 18th, 2009 04:16 pm (UTC)
I thought that was the case. I put the feet behind the cut so you can scroll without dread of icky feet.
machmed
Mar. 19th, 2009 03:08 am (UTC)
Well thanks. :p
( 7 comments — Leave a comment )

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