High Fructose Corn Syrup Does NOT Metabolize in the Same Way as Sugar
HFCS is a highly processed product that contains similar amounts of unbound fructose and glucose. Sucrose, on the other hand, is a larger sugar molecule that is metabolized into glucose and fructose in your intestine.
Part of what makes HFCS such an unhealthy product is that it is metabolized to fat in your body far more rapidly than any other sugar, and, because most fructose is consumed in liquid form, its negative metabolic effects are significantly magnified.
Whereas the glucose in other sugars is used by your body, and is converted to blood glucose, fructose is a relatively unregulated source of fuel that your liver converts to fat and cholesterol.
There are over 35 years of hard empirical evidence that refined man-made fructose like high fructose corn syrup metabolizes to triglycerides and adipose tissue, not blood glucose. The downside of this is that fructose does not stimulate your insulin secretion, nor enhance leptin production. (Leptin is a hormone thought to be involved in appetite regulation.)
Because insulin and leptin act as key signals in regulating how much food you eat, as well as your body weight, this suggests that dietary fructose may contribute to increased food intake and weight gain.
Additionally, fructose is also known to significantly raise your triglycerides and LDL (bad cholesterol).
Triglycerides, the chemical form of fat found in foods and in your body, are not something you want in excess amounts. Intense research over the past 40 years has confirmed that elevated blood levels of triglycerides, known as hypertriglyceridemia, puts you at an increased risk of heart disease.