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Dangerous Pharmaceuticals: FDA's Top 20

A 2007 federal law requires the FDA to disclose all its investigations into reports of possibly drug-related adverse events. The first of this series of quarterly reports has been released. It includes adverse events reported between January 1 and March 31, 2008.

Here's the list of drugs and the adverse events that have been reported:

1. Arginine Hydrochloride Injection (R-Gene 10) -- Pediatric overdose due to labeling and packaging confusion

2. Desflurane (Suprane) -- Cardiac arrest

3. Duloxetine (Cymbalta) -- Urinary retention

4. Etravirine (Intelence) -- Hemarthrosis (blood in a joint)

5. Fluorouracil Cream (Carac) and Ketoconazole Cream (Kuric) -- Adverse events due to name confusion

6. Heparin -- Anaphylactic-type (life-threatening allergic) reactions

7. Icodextrin (Extraneal) -- Hypoglycemia (low blood sugar)

8. Insulin U-500 (Humulin R) -- Dosing confusion

9. Ivermectin (Stromectol) and Warfarin -- Drug interaction

10. Lapatinib (Tykerb) -- Hepatotoxicity (liver toxicity)

11. Lenalidomide (Revlimid) -- Stevens-Johnson syndrome (a deadly drug reaction)

12. Natalizumab (Tysabri) -- Skin melanomas (deadly skin cancer)

13. Nitroglycerin (Nitrostat) -- Overdose due to labeling confusion

14. Octreotide Acetate Depot (Sandostatin LAR) -- Ileus (bowels not moving)

15. Oxycodone Hydrochloride Controlled-Release (OxyContin) -- Drug misuse, abuse, and overdose

16. Perflutren Lipid Microsphere (Definity) -- Cardiopulmonary reactions (lung/heart problems)

17. Phenytoin Injection (Dilantin) -- Purple glove syndrome (discoloration, pain, and swelling of the hand that may lead to amputation)

18. Quetiapine (Seroquel) -- Overdose due to sample pack labeling confusion

19. Tebivudine (Tyzeka) -- Peripheral neuropathy (tingling or numbness in the extremities)

20. Tumor Necrosis Factor (TNF) Blockers -- Cancers in children and young adults

SOURCES
ttp://www.webmd.com/news/20080905/20-drugs-fda-is-watching
http://articles.mercola.com/sites/articles/archive/2008/09/27/fda-announces-20-dangerous-drugs-you-should-not-be-on.aspx?source=nl
http://www.fda.gov/cder/aers/potential_signals/potential_signals_2008Q1.htm?source=time

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