liveonearth (liveonearth) wrote,
liveonearth
liveonearth

Psoriasis Triples Heart Attack Risk for under 50 Crowd

You may be surprised to learn that having the common skin disease psoriasis may triple your risk of a heart attack if you're under age 50. This finding results from five years of medical data collected on British patients. It appears that both psoriasis and athlerosclerosis are mediated by T-cell (immune) mediated inflammation, so the correlation could result from a shared cause.

(swiped from Mercola at: http://v.mercola.com/blogs/public_blog/Psoriasis-Can-Triple-Your-Heart-Attack-Risks-1142.aspx
Here's the article he was reviewing:
http://jama.ama-assn.org/cgi/content/full/296/14/1735

The rest of what Mercola had to say:

A bit surprising, but it's true a 30-year-old patient with psoriasis taking a conventional medication has a 300 percent greater chance of succumbing to a heart attack, while a 60-year-old's risks grew by just 36 percent.

I suspect the incidence of psoriasis has much to do with a lack of daily sunshine exposure that prevents your skin from generating the vitamin D your body vitally needs. And, it makes sense, considering the lack of vitamin D contributes to congestive heart failure too. You'll also want to review Dr. Carolyn Dean's recommendations -- among them boosting your omega-3 fatty acid levels -- to treat psoriasis safely and effectively.


Risk of Myocardial Infarction in Patients With Psoriasis
Joel M. Gelfand, MD, MSCE; Andrea L. Neimann, MD; Daniel B. Shin, BA; Xingmei Wang, MS; David J. Margolis, MD, PhD; Andrea B. Troxel, ScD

JAMA. 2006;296:1735-1741.

ABSTRACT

Context
Psoriasis is the most common T-helper cell type 1 (TH1) immunological disease. Evidence has linked TH1 diseases to myocardial infarction (MI). Psoriasis has been associated with cardiovascular diseases, but has only been investigated in hospital-based studies that did not control for major cardiovascular risk factors.

Objective
To determine if within a population-based cohort psoriasis is an independent risk factor for MI when controlling for major cardiovascular risk factors.

Design, Setting, and Patients
A prospective, population-based cohort study in the United Kingdom of patients with psoriasis aged 20 to 90 years, comparing outcomes among patients with and without a diagnosis of psoriasis. Data were collected by general practitioners as part of the patient's medical record and stored in the General Practice Research Database between 1987 and 2002, with a mean follow-up of 5.4 years. Adjustments were made for hypertension, diabetes, history of myocardial infarction, hyperlipidemia, age, sex, smoking, and body mass index. Patients with psoriasis were classified as severe if they ever received a systemic therapy. Up to 5 controls without psoriasis were randomly selected from the same practices and start dates as the patients with psoriasis. A total of 556 995 control patients and patients with mild (n = 127 139) and severe psoriasis (n = 3837) were identified.

Results
There were 11 194 MIs (2.0%) within the control population and 2319 (1.8%) and 112 (2.9%) MIs within the mild and severe psoriasis groups, respectively. The incidences per 1000 person-years for control patients and patients with mild and severe psoriasis were 3.58 (95% confidence interval [CI], 3.52-3.65), 4.04 (95% CI, 3.88-4.21), and 5.13 (95% CI, 4.22-6.17), respectively. Patients with psoriasis had an increased adjusted relative risk (RR) for MI that varied by age. For example, for a 30-year-old patient with mild or severe psoriasis, the adjusted RR of having an MI is 1.29 (95% CI, 1.14-1.46) and 3.10 (95% CI, 1.98-4.86), respectively. For a 60-year-old patient with mild or severe psoriasis, the adjusted RR of having an MI is 1.08 (95% CI, 1.03-1.13) and 1.36 (95% CI, 1.13-1.64), respectively.

Conclusions
Psoriasis may confer an independent risk of MI. The RR was greatest in young patients with severe psoriasis.
Tags: cardiovascular, immunology, inflammation, psoriasis, skin
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