Bile Salt Formation
What the first step in making bile?
7 alpha hydroxylation of cholesterol
this is the rate limiting step, inhibited by presence of bile acids
cyp enzyme requires iron 2+ and NADPH, and forms water
What happen to iron in the reaction?
Fe2+-->3+
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7 alpha hydroxylation of cholesterol
this is the rate limiting step, inhibited by presence of bile acids
cyp enzyme requires iron 2+ and NADPH, and forms water
What happen to iron in the reaction?
Fe2+-->3+
( Collapse )
